[All remote jobs](https://jobicy.com/jobs.md)[![Veracyte logo](https://jobicy.com/data/server-nyc0409/galaxy/mercury/2025/08/1917a215-221.jpeg)](https://jobicy.com/company/veracyte.md)[Veracyte](https://jobicy.com/company/veracyte.md) # Senior Bioinformatics Scientist Review the role, location requirements, compensation details, and application process before deciding whether this opportunity fits your next career move. [Apply for this job](#job-application)[View company](https://jobicy.com/company/veracyte.md)ShareRemote from[USA](https://jobicy.com/job-region/usa.md)SalaryUSD 150k–189k / yrDepartment[Data Science & Analytics](https://jobicy.com/categories/data-science.md)EmploymentFull TimeExperienceSeniorPublished27 Oct 2026Apply before26 Nov 2026Listing views34Application actions1Application toolkit ## Make your next move. Prepare your resume, explore your fit, and draft a cover letter for this opportunity. AI Summary ## The role, at a glance. Veracyte is seeking a senior bioinformatics scientist to lead the development and validation of next-generation ctDNA-based minimal residual disease diagnostics. The role owns production-ready NGS bioinformatics pipelines, including quality control, variant calling, MRD calling, error modeling, and longitudinal tracking. It requires deep experience with clinical assay development under CAP/CLIA or comparable design-control frameworks, plus close partnership with wet-lab, clinical, regulatory, quality, and software teams. The scientist will also contribute to regulatory documentation, mentor junior colleagues, and communicate technical decisions to senior stakeholders. ## Role DNA A quick view of the complexity, pace, ownership and collaboration implied by the job description. ### Job Complexity 5/5EasyHard ### Pace & Pressure 4/5RelaxedFast-paced ### Autonomy Level 5/5GuidedFull ownership ### Communication Load 5/5IndependentCollaborative AI insightThis is a highly specialized senior role combining cancer genomics, production software, clinical assay validation, and regulated diagnostic development. Success requires independent technical ownership while making defensible scientific decisions across multiple cross-functional teams. ## Salary analysis Estimated compensation compared with the broader US market for similar roles. Estimated job median (per year)Market rate$169,500US market range (per year)$150k–$195k0$214.50k AI insightThe yearly pay period is inferred from the job context; it was not explicitly stated by the employer. The employer discloses a base-pay range of $150,000–$189,000 USD. The posting does not explicitly state the cadence, but yearly pay is inferred from the salary magnitude, US location, seniority, and standard full-time biotech compensation practice. A reasonable estimated US market range for a senior bioinformatics scientist in regulated oncology diagnostics is $150,000–$195,000 per year. ## Core skills Skills and capabilities most closely associated with this opportunity. [Bioinformatics](https://jobicy.com/jobs?search_keywords=Bioinformatics.md)[NGS assay development](https://jobicy.com/jobs?search_keywords=NGS%20assay%20development.md)[ctDNA analysis](https://jobicy.com/jobs?search_keywords=ctDNA%20analysis.md)[Minimal residual disease](https://jobicy.com/jobs?search_keywords=Minimal%20residual%20disease.md)[Cancer genomics](https://jobicy.com/jobs?search_keywords=Cancer%20genomics.md)[Python](https://jobicy.com/jobs?search_keywords=Python.md)[Variant calling](https://jobicy.com/jobs?search_keywords=Variant%20calling.md)[Analytical validation](https://jobicy.com/jobs?search_keywords=Analytical%20validation.md)[CAP/CLIA compliance](https://jobicy.com/jobs?search_keywords=CAPCLIA%20compliance.md)[Clinical diagnostics](https://jobicy.com/jobs?search_keywords=Clinical%20diagnostics.md)[Pipeline development](https://jobicy.com/jobs?search_keywords=Pipeline%20development.md)[AWS](https://jobicy.com/jobs?search_keywords=AWS.md)[Statistical analysis](https://jobicy.com/jobs?search_keywords=Statistical%20analysis.md)[Regulatory documentation](https://jobicy.com/jobs?search_keywords=Regulatory%20documentation.md)[Cross-functional collaboration](https://jobicy.com/jobs?search_keywords=Cross-functional%20collaboration.md) Sample interview questionsHow would you design an analytical validation strategy for a ctDNA-based MRD assay?I would define intended use and critical performance claims first, then design representative studies for accuracy, sensitivity or limit of detection, specificity, precision, reproducibility, reportable range, and interference. I would use well-characterized reference materials and clinical samples where appropriate, predefine acceptance criteria, and document traceability under the applicable quality system. What approaches would you use to reduce sequencing and background errors in an ultra-sensitive MRD pipeline? I would combine molecular barcoding or UMI-aware consensus generation with stringent read- and molecule-level quality control. I would also model site- and context-specific background error, use appropriate germline and clonal hematopoiesis filtering strategies, and benchmark sensitivity and false-positive performance on negative controls and longitudinal samples. Describe how you would make a bioinformatics workflow production-ready in a regulated diagnostic environment. I would version code, reference data, parameters, environments, and workflow outputs; define requirements and test cases; and establish automated testing and controlled releases. The workflow would have audit-ready documentation, reproducible execution, change control, validation evidence, monitoring, and clear procedures for incident investigation and corrective action. How do you collaborate effectively with wet-lab scientists during assay optimization? I translate analytical observations into testable experimental hypotheses and agree on measurable success criteria before each iteration. I regularly review controls, library-preparation variables, sequencing metrics, and failure modes with wet-lab partners so that experimental and computational changes are evaluated as one integrated assay. How would you communicate a complex performance trade-off, such as improved sensitivity with increased false-positive risk, to non-computational leadership? I would frame the decision around patient and clinical impact, using concise visuals and plain-language definitions of the relevant metrics. I would quantify the expected benefit and risk, state assumptions and uncertainty, present viable options, and recommend an approach tied to the assay's intended use and regulatory requirements. Opportunity details ## About this role. At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees to not only make a meaningful impact on the lives of patients, but to also learn and grow within a purpose driven environment. This is what we call the Veracyte way – it’s about how we work together, guided by our values, to give clinicians the insights they need to help patients make life-changing decisions. Our Values: * We Seek A Better Way: We pursue bold ideas, embrace complexity, and keep pushing forward. * We Make It Happen: We act with urgency, deliver with excellence, and always find a way. * We Are Stronger Together: We engage with empathy, align around what’s best for Veracyte, and celebrate as one team. * We Care Deeply: We show up with integrity, kindness, and respect for one another. ### The Position: We are seeking a highly experienced and motivated Senior Bioinformatics Scientist to drive the design, and development of next‑generation minimal residual disease (MRD) laboratory‑developed tests (LDTs). This senior, independent scientist position is responsible for contributing to assay concepts, driving analytical development and validation, and partnering closely with wet‑lab, clinical, quality, regulatory, and software teams to deliver robust, clinically actionable MRD diagnostics for multiple indications. The ideal candidate brings expertise in NGS‑based oncology assays, strong understanding of ctDNA biology and a proven track record of industry assay development under design control. This individual will lead technical execution of key scientific efforts, owning assay bioinformatics from concept through analytical validation and launch. KEY RESPONSIBILITIES: Scientific & Technical Expertise * Contribute to bioinformatics strategy for MRD assay design, development, optimization, and lifecycle management for LDTs developed under CAP/CLIA quality systems. * Lead and contribute to study design, data analysis, performance characterization, and decision‑making throughout development. * Apply deep domain knowledge in cancer genomics, ctDNA biology, and NGS technologies to inform assay architecture, variant detection strategies, and error suppression approaches in collaboration with our data science and modeling teams. Assay Development & Validation * Design and execute analytical studies to evaluate assay performance, including accuracy, limit of detection, and reproducibility, in collaboration with wet‑lab and biostatistics partners. * Develop, validate, and maintain scalable, production‑ready bioinformatics pipelines for MRD analysis, including QC, variant calling, MRD calling logic, and reporting. * Lead benchmarking and optimization of computational methods, including background error modeling, and longitudinal MRD tracking. * Ensure compliance with standards (CAP/CLIA, FDA, IVDR) throughout the bioinformatics development lifecycle, including rigorous testing and documentation. Cross‑Functional Collaboration * Partner closely with molecular biology, assay development, QA/RA, clinical, and software engineering teams to ensure bioinformatics solutions are aligned with assay design, regulatory expectations, and operational constraints. * Contribute to regulatory submissions and audits by providing technical documentation and validation report, and responses to audits or regulatory inquiries. Mentorship & Influence * Provide technical mentorship and scientific guidance to junior scientists, helping raise the overall bar of assay development rigor and execution. * Communicate complex analytical concepts and results clearly to both computational and non‑computational stakeholders, including senior leadership. ### Who You Are: REQUIRED EXPERIENCE: * Ph.D. in Bioinformatics, Computational Biology, Genomics, Biostatistics, or a closely related quantitative field. (or M.Sc. plus 3 additional years industry experience). * Minimum 6 years of total relevant experience in biotech, diagnostics, or regulated healthcare environments. * Demonstrated experience in NGS‑based assay development for clinical diagnostics. Hands‑on experience with ctDNA‑based MRD assays, including personalized or tumor‑informed approaches. * Strong programming skills in Python, with experience developing reproducible, production‑grade analysis pipelines, including experience with SDLC best practices. * Proven experience working in design‑controlled, regulated environments (CAP/CLIA LDT, IVD, or equivalent). * Proficiency in development of novel bioinformatics methodologies, and algorithms development, including benchmarking of computational methods. * Track record of working with wet lab scientists on iterative experiment design, execution, analysis, and interpretation as a tightly integrated team. * Demonstrated record of technical and scientific ownership, and independent work. PREFERRED EXPERIENCE: * Experience developing and deploying bioinformatics workflows in AWS (e.g., EC2, S3, Step Functions, Batch, Lambda, etc.). * Strong understanding of germline and somatic mutation processes leading to complex variation and genome-wide biomarkers with potential clinical utility. * Working knowledge of R. * Experience with relational and non-relational database technologies is a plus. #LI-Onsite, #LI-Hybrid, or #LI-Remote For candidates based in our San Diego office, the salary range is $160,000 – $180,000. For candidates based in our South San Francisco office, the salary range is $175,000 – $189,000. For candidates working remote (US), the salary range is $150,000 – $168,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to years of experience, skillset, geographic location, industry, education, etc. Base pay is one part of the Total Package that is provided to compensate and recognize employees for their work, and this role may be eligible for additional discretionary bonuses/incentives, and restricted stock units. Pay range $150,000—$189,000 USD ### What We Can Offer You Veracyte is a growing company that offers significant career opportunities if you are curious, driven, patient-oriented and aspire to help us build a great company. We offer competitive compensation and benefits, and are committed to fostering an inclusive workforce, where diverse backgrounds are represented, engaged, and empowered to drive innovative ideas and decisions. We are thrilled to be recognized as a 2024 Certified™ Great Place to Work® in both the US and Israel – a testament to our dynamic, inclusive, and inspiring workplace where passion meets purpose. ### About Veracyte Veracyte (Nasdaq: VCYT) is a global diagnostics company whose vision is to transform cancer care for patients all over the world. We empower clinicians with the high-value insights they need to guide and assure patients at pivotal moments in the race to diagnose and treat cancer. Our Veracyte Diagnostics Platform delivers high-performing cancer tests that are fueled by broad genomic and clinical data, deep bioinformatic and AI capabilities, and a powerful evidence-generation engine, which ultimately drives durable reimbursement and guideline inclusion for our tests, along with new insights to support continued innovation and pipeline development. For more information, please visit [www.veracyte.com](https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.veracyte.com%2F&esheet=54340020&newsitemid=20251015446872&lan=en-US&anchor=www.veracyte.com&index=5&md5=4d48386b00ece1531372e2e593d7cd2d) or follow us on [LinkedIn](https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fveracyte%2F&esheet=54340020&newsitemid=20251015446872&lan=en-US&anchor=LinkedIn&index=6&md5=234cba826cb637f449d2722139f551ef) or [X (Twitter)](https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fx.com%2Fveracyte%3Fs%3D11&esheet=54340020&newsitemid=20251015446872&lan=en-US&anchor=X+%28Twitter%29&index=7&md5=20ead95735af622bf261b20735515b66). Veracyte, Inc. is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability status. 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