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Bioinformatics Scientist
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- Remote from
- USA
- Salary
- USD 101,800–127,300 / yr
- Department
- Data Science & Analytics
- Employment
- Full Time
- Experience
- Senior
- Published
- Apply before
- 18 Nov 2026
- Listing views
- 19
- Application actions
- 2
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The role, at a glance.
Natera is hiring a Bioinformatics Scientist to analyze high-throughput cancer genomics data for recurrence monitoring. The role combines NGS analysis, algorithm and statistical-method development, experimental design, quality control, and production-oriented bioinformatics pipeline work. The scientist will collaborate closely with molecular biologists and other bioinformatics specialists to answer biological questions and communicate findings. Candidates need at least two years of hands-on sequencing-analysis experience, strong Python and Linux skills, and a solid grounding in genomics; cancer biology, machine learning, statistics, and WGS experience are preferred.
Role DNA
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Pace & Pressure
4/5Autonomy Level
4/5Communication Load
4/5Salary analysis
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Core skills
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Sample interview questions
I would explain the pipeline inputs, preprocessing and alignment steps, variant-calling approach, quality metrics, and reporting outputs. I would also describe how I made it reproducible through version control, parameterized workflows, test datasets, and documented validation criteria.
I would first review sample and library QC, coverage uniformity, mapping quality, duplicate rates, contamination signals, and batch effects. I would then compare processing parameters and controls, assess whether the issue is biological or technical, and use targeted experiments or simulations to validate potential changes.
I would define the intended use and success metrics, then evaluate the method with representative truth sets, controls, and independent holdout data. I would measure sensitivity, specificity, precision, robustness across sequencing conditions, and failure modes, while documenting assumptions and versioned results.
I tailor the explanation to the scientific decision being made, use clear visualizations and concise conclusions, and distinguish observed results from interpretation. I also provide enough methodological context and limitations for collaborators to evaluate confidence and plan follow-up experiments.
I would assess data provenance, cohort composition, genome build, assay type, annotation version, licensing, and clinical interpretation scope. I would harmonize formats and identifiers carefully, track database versions, and avoid overgeneralizing findings beyond the source population or evidence level.
About this role.
Natera is seeking a Bioinformatics Scientist to join our Bioinformatics Research & Development team with a focus on cancer recurrence monitoring. Natera’s mission is to change the management of disease worldwide with a focus on reproductive health, cancer, and organ transplantation.
The ideal candidate should have experience in sequencing data analysis, genomics, and/or algorithm development. This individual will analyze large and complex high-throughput cancer genomics datasets. They will also assist in developing novel computational methods, and integrating frameworks developed by our R&D team.
PRIMARY RESPONSIBILITIES:
- Analyze high-throughput DNA sequencing datasets utilizing understanding of cancer biology and genomics. Help implement and validate novel algorithms and statistical methods.
- Collaborate with molecular biologists and other bioinformatics scientists to answer biological questions
- Contribute to experimental design and quality control
- Help develop tools and end-to-end bioinformatics pipelines
QUALIFICATIONS:
- Bachelor’s degree in bioinformatics, computational biology, computer science, engineering, molecular biology, or a related field; Master’s degree preferred
- Minimum of 2 years of hands-on experience doing high-throughput genomic sequencing analysis
KNOWLEDGE, SKILLS, AND ABILITIES:
- Experience doing NGS data analysis (e.g. mapping, variant calling, etc.)
- Strong programming skills in a scientific programming language, Python strongly preferred
- Knowledge of genomics, with a preference for familiarity with cancer biology
- Familiarity with public databases such as TCGA, COSMIC, or OncoKB
- Experience with Linux command-line tools and shell scripting
- Ability to conduct hypothesis-driven research, visualize data, and effectively communicate results
- Ability to collaborate effectively, self-motivated, and detail-oriented
PREFERRED SKILLS:
- Background in ML and statistics
- Experience with WGS
The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.
Remote USA
$101,800—$127,300 USD
OUR OPPORTUNITY
Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
WHAT WE OFFER
Competitive Benefits – Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!
For more information, visit www.natera.com.
Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.
If you are based in California, we encourage you to read this important information for California residents.
Link: https://www.natera.com/notice-of-data-collection-california-residents/
Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
For more information:
– BBB announcement on job scams
– FBI Cyber Crime resource page
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