Principal Statistician Consultant-R&I (Respiratory & Immunology) REMOTE@EU/UK

Remote from: UK, Europe
Annual salary: Undisclosed
Salary information is not provided for this position. Check our Salary Directory to estimate the average compensation for similar roles.
Department: Data Science & Analytics
Employment type: Full Time,
Job posted: 16 Jun 2026
Apply before: 16 Jul 2026
Experience level: Senior
Views / Applies: 13 / 4

Medical innovation with over 25 years of trust and experience.

Pharmaceuticals
1997

AI Summary

This role is a Principal Biostatistician Consultant position within the Respiratory & Immunology team at ClinChoice, a global CRO. The consultant will work directly with a sponsor on clinical trial design, statistical analysis, and regulatory submissions. Responsibilities include protocol development, sample size calculation, statistical oversight, and mentoring junior statisticians. The ideal candidate holds an MS or PhD in Statistics with 5-7+ years of experience, strong SAS and R skills, and specific expertise in respiratory and immunology studies. The position is remote and offers the opportunity to be part of a supportive, quality-focused organization.

Role DNA

Job Complexity

Easy Hard

Pace & Pressure

Relaxed Fast-paced

Autonomy Level

Guided Full Ownership

Communication Load

Independent Highly Collaborative

AI Insight The role requires advanced statistical expertise, regulatory knowledge, and leadership in a high-stakes clinical trial environment, making it extremely challenging.

Salary Analysis

AI Insight The offered salary is not specified, but for a Principal Biostatistician Consultant with specialized respiratory and immunology experience, the US market range is $130,000-$180,000. This role typically offers competitive compensation given the seniority and niche expertise required.

Key Skills

Biostatistics Clinical Trials SAS R FDA Regulations Respiratory & Immunology CRO Oversight Statistical Analysis Mentoring Protocol Development

Cover Letter Sample

I am writing to express my strong interest in the Principal Statistician Consultant position within your Respiratory & Immunology team. With a PhD in Biostatistics and over 6 years of experience in clinical trials, including extensive work on respiratory studies, I am confident in my ability to deliver high-quality statistical leadership.

My expertise includes protocol development, sample size calculations, and regulatory submissions, with proficiency in SAS and R. I have successfully mentored junior statisticians and provided oversight for CROs, ensuring timely and accurate deliverables.

I am particularly drawn to ClinChoice’s reputation for quality and supportive culture, and I am excited about the opportunity to contribute to innovative treatments in respiratory and immunology.

Thank you for considering my application. I look forward to discussing how my skills align with your team’s needs.

Possible Interview Questions

How do you handle missing data in clinical trials?

Missing data is a common issue, and my approach depends on the mechanism. For MAR, I often use multiple imputation or mixed models for repeated measures. For MNAR, I might perform sensitivity analyses using pattern-mixture models or tipping point analyses. Transparency and pre-specification in the SAP are key.

Describe a time you had to explain complex statistical results to a non-statistical audience.

I once presented subgroup analysis results to a clinical team. I focused on visual aids like forest plots and explained the confidence intervals and p-values in plain language, emphasizing clinical relevance over statistical significance. This helped the team make informed decisions.

What is your experience with adaptive trial designs?

I have used adaptive designs such as group sequential designs for interim analyses and sample size re-estimation. For example, in a Phase IIb respiratory trial, we implemented a futility interim to stop early if the drug showed no benefit, which saved resources and time.

How do you ensure quality control in statistical programming?

I follow a strict QC process: independent programming by a second statistician, code review, and validation using simulated data. I also use version control and check consistency between TLFs and the statistical report. Regular audits ensure adherence to SOPs.

How do you mentor junior statisticians?

I provide hands-on training in SAS and R, review their code and outputs, and discuss statistical methodology. I encourage them to ask questions and present their work in team meetings. I also assign progressively challenging tasks to build their confidence and skills.

Are you interested in working directly for a single sponsor while having the security and additional career opportunities that working for a global CRO can bring? Our team says it’s the best of both worlds….

ClinChoice is searching for a Principal Biostatistician Consultant to join one of our clients at Respiratory & Immunology team.

ClinChoice is a global full-service CRO with a strong focus on quality, professional development, and supportive culture. As a client-facing role, we are looking for confident candidates with the ability to work independently whilst establishing a high-trust environment with the client’s counterparts.

Main Job Tasks and Responsibilities:

Responsible for protocol development including study design, sample size calculation, randomization, and statistical analysis plan for assigned studies.
Provide statistical oversight to studies and assure adequate quality and consistency with project requirements.
Responsible for assuring that data for statistical analyses are complete, accurate and consistent.
Responsible for statistical analysis plans and the accuracy and timeliness of statistical input into reports or decisions.
Responsible for validity of analysis and explore alternative analysis strategies as needed.
Demonstrates extensive understanding of statistical concepts and methodologies. Recognizes and corrects flaws in scientific reasoning and statistical interpretation.
Responsible for accuracy and consistency of statistical tables, figures, and data listings, accuracy of report text, and consistency between summary tables in the body of reports and the corresponding source tables and listings.
Responsible for statistical methods section for the reports. Identifies and corrects common flaws in interpretation of results, inconsistency in presentation or inference, adherence to the report guidelines, and assures project-wide consistency.
Effectively mentor peers with regards to statistical methodology and provide appropriate training to less experienced statisticians.
Manage activities of statisticians across projects by appropriately coordinating assignments and reviewing work so that projects are delivered on time with high quality.

Education and Experience:

MS or PhD in Statistics, Biostatistics or related field. PhD with 2-4 years of experience or MS with 5-7 years of experience
Strong SAS skills.
Interpretation of data for internal team (clinical, stats,..).
Require lead experience who can program utilizing SAS and R, and has experience with providing CRO oversight.
Working on study readouts ( AKA) analysis results from Tables listings and figures.
Require Respiratory & Immunology TA experience. (Asthma Study)
Strong oral and written communications skills, with ability to effectively communicate internally and with clients.
Demonstrated understanding and insight in statistics, drug development process and relevant FDA regulations.
Pharmaceutical, CRO, or related industry experience with clinical trials, including interaction with Regulatory Agencies, especially FDA.

The Application Process

Once you have submitted your CV, you will receive an acknowledgement that we received it. If you have the requirements we need, you will be invited for phone interview as the first step. Unfortunately, due to the number of applications we receive, we cannot reply to everyone individually if you are not successful.

Who will you be working for?

About ClinChoice

ClinChoice is a global full-service CRO specializing in clinical development and functional solutions for pharmaceutical, biotechnology, medical device, and consumer health companies. We have over 28 years of proven high-quality delivery and results across all our services, with over 4,000 professionals in more than 20 countries across the Americas, Europe, and Asia-Pacific.

Our Company Ethos

Our mission drives our culture: to contribute to a healthier and safer world by accelerating the development and commercialization of innovative drugs and devices. Our employees are the most valuable company asset and they are the fulcrum around which all ClinChoice activities are built and close management and training is the core instrument to develop and maintain highly-qualified personnel. The continuous training keeps the resources qualified in terms of competence and expertise and gives all personnel the clear tools needed to manage both internal and client processes with the same methodology. The success of these core values is evidenced by our below industry average turnover rates.

ClinChoice is an equal opportunity employer. We have based our success on attracting, developing, and promoting talent guided by diversity and inclusivity. Our employees come from very diverse backgrounds: gender, race, beliefs, and ethnicities. We recognize this is our strength and celebrate it.

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