Bioinformatics Manager (Oncology Product Development)

Remote from: USA
Annual salary: Undisclosed
Salary information is not provided for this position. Check our Salary Directory to estimate the average compensation for similar roles.
Department: Data Science & Analytics
Employment type: Full Time,
Job posted: 22 Jul 2026
Apply before: 22 Aug 2026
Experience level: Midweight
Views / Applies: 24 / 2

About company

About Natera

Transforming patient care through genetic testing and precision medicine.

Biotechnology
2004

Actively Hiring

AI Summary

Natera is seeking a Bioinformatics Manager to lead a team focused on oncology product development. The role involves managing bioinformaticians and data scientists, providing technical leadership for ctDNA-based diagnostic tests, and collaborating cross-functionally. The ideal candidate has a strong background in bioinformatics, data science, and experience with DNA methylation data. Responsibilities include developing analysis pipelines, supervising staff, and contributing to intellectual property. The position requires a Master's or PhD in a quantitative field and 4-8 years of experience.

Role DNA

Job Complexity

Easy Hard

Pace & Pressure

Relaxed Fast-paced

Autonomy Level

Guided Full Ownership

Communication Load

Independent Highly Collaborative

AI Insight This role requires an advanced degree, significant experience, and management responsibilities, making it challenging. The technical complexity of oncology diagnostics adds to the difficulty.

Salary Analysis

AI Insight The offered salary range of $140,000-$175,000 is competitive for a Bioinformatics Manager role in the US market, aligning with industry standards for experienced professionals.

Core Skills Required

Bioinformatics Data Science DNA Methylation Next-Generation Sequencing Python R Machine Learning Statistical Modeling Product Development Team Leadership

Cover Letter Sample

Dear Hiring Manager,

I am excited to apply for the Bioinformatics Manager position at Natera. With a PhD in Bioinformatics and over 6 years of experience in oncology product development, I have successfully led teams in developing NGS-based diagnostic tests. My expertise in DNA methylation analysis and machine learning aligns perfectly with your needs.

I have a proven track record of moving algorithms from research to commercialization, and I thrive in cross-functional environments. I am eager to bring my leadership and technical skills to Natera to advance ctDNA testing.

Thank you for considering my application. I look forward to discussing how I can contribute to your team.

Sincerely,
[Your Name]

Sample Interview Questions

Describe your experience with developing and optimizing bioinformatics pipelines for NGS data.

I have led the development of pipelines for variant calling and methylation analysis using tools like BWA, GATK, and custom scripts in Python. I optimized them for scalability and accuracy, reducing runtime by 30%.

How do you approach managing a team of bioinformaticians and data scientists?

I set clear goals, delegate tasks based on strengths, and hold regular one-on-ones. I encourage continuous learning and ensure alignment with project milestones.

Can you provide an example of a product you moved from research to commercial launch?

I led the development of a ctDNA assay for early cancer detection. I oversaw validation studies, obtained regulatory approval, and collaborated with manufacturing for scale-up.

Explain a complex statistical model you implemented for biomarker discovery.

I used a Bayesian hierarchical model to identify methylation signatures from liquid biopsy data, accounting for batch effects and sample heterogeneity.

How do you ensure rigorous data analysis and documentation?

I enforce version control, code review, and automated testing. I maintain detailed documentation for reproducibility and regulatory compliance.

Natera is currently seeking a Bioinformatics Manager to join the Bioinformatics team focused on Oncology Product Development. In this role, the individual will manage a team of Bioinformaticians and Data Scientists and provide technical leadership in the design, development and validation of ctDNA-based diagnostic tests. This position requires extensive cross-functional collaboration with biostatistics, molecular biology, software engineering and commercial departments. The ideal candidate will have a strong background in bioinformatics and data science, optimally with experience in the analysis or modeling of DNA methylation data, and an established record of project and technical leadership.

PRIMARY RESPONSIBILITIES:

Lead the effort to develop, optimize, and improve tools and analysis pipelines for diagnostic tests, including the detection of cancer-associated variants or methylation patterns and the implementation of evidence-based quality control thresholds.
Provide technical leadership for product development projects by representing the team in cross-functional interactions and moving products through the full development process, from research through commercial launch.
Supervise bioinformatics scientists and data scientists, managing their technical contributions, prioritizing resources, and taking responsibility for their technical and professional development.
Provide input on experiment design, analysis and interpretation based on expert understanding of Natera’s technology and relevant mathematical principles.
Work at a high level of independence and responsibilities in carrying out assignments.
Contribute to our intellectual property portfolio.
Set standards for rigorous data analysis and lead the production of high-quality documentation.

QUALIFICATIONS:

Master’s degree or Ph.D. in a quantitative discipline (bioinformatics, engineering, applied mathematics, statistics, or similar).
Minimum of 4-8 years of post-graduate experience in a data science and/or bioinformatics role and 1-3 years of experience as technical lead in diagnostics or a related field
Experience moving algorithm-based products through commercialization and launch in a medical or biological application such as diagnostic testing, medical imaging, or biotechnology

Desirable, but not required:

Prior experience analyzing or modeling DNA methylation data.

KNOWLEDGE, SKILLS, AND ABILITIES:

Experience using Python or R for scientific data analysis and visualization.
Strong foundation in statistical modeling/machine learning, including probability theory and estimation/classification methods.
Experience with analysis of next-generation sequencing data, preferably including algorithm development or optimization.
Proven ability to apply mathematical principles to solve real estimation problems and implement practical solutions.
Excellent analytical, problem-solving and decision-making skills to independently make sound judgments and find creative solutions to moderately complex problems.
Experience leading technical projects, including defining and meeting project milestones, delegating tasks to more junior team members, and ensuring the quality of technical deliverables.
Excellent communication skills and the desire to work in a dynamic and collaborative environment.

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

Remote USA

$140,000—$175,000 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits – Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:
– BBB announcement on job scams
– FBI Cyber Crime resource page

Apply now >