About this role.
Natera is seeking an experienced HEOR leader to develop economic and outcomes evidence for oncology precision molecular diagnostics. The role leads cost-effectiveness, budget-impact, cost-utility, ROI, and real-world evidence analyses that support payer coverage, reimbursement, and clinical adoption. It partners extensively with Clinical Development, Medical Affairs, Biostatistics, Market Access, Commercial, Regulatory, and external research collaborators. The successful candidate will shape evidence strategy across the product lifecycle and translate complex findings into publications, value dossiers, payer tools, and executive communications. This is a senior, remote U.S. position requiring substantial HEOR, oncology, and market-access expertise.
Role DNA
A quick view of the complexity, pace, ownership and collaboration implied by the job description.
Job Complexity
5/5Pace & Pressure
4/5Autonomy Level
5/5Communication Load
5/5Salary analysis
Estimated compensation compared with the broader US market for similar roles.
Core skills
Skills and capabilities most closely associated with this opportunity.
Sample interview questions
I would first define the decision problem, including the target population, comparator pathways, payer perspective, time horizon, and relevant clinical outcomes. I would select an appropriate model structure, such as a decision tree followed by a Markov or partitioned-survival model, then populate it with evidence from trials, real-world data, literature, and validated assumptions. Finally, I would conduct deterministic and probabilistic sensitivity analyses and clearly communicate uncertainty, budget implications, and decision-relevant value drivers.
I would partner early with Clinical Development, Medical Affairs, and Biostatistics to identify payer-relevant evidence gaps and incorporate feasible endpoints such as healthcare resource utilization, treatment patterns, patient-reported outcomes, quality of life, and diagnostic impact. I would ensure the statistical analysis plan supports these objectives and that data collection is consistent with downstream reimbursement and HTA needs. Throughout the study, I would maintain a plan for translating results into publications, economic models, and value communications.
I begin by understanding the audience's decision context, such as total cost of care, budget predictability, clinical utility, or pathway efficiency. I then translate the technical analysis into concise, evidence-based messages supported by transparent assumptions, scenario analyses, and visually clear summaries. I preserve scientific rigor while tailoring the format into tools such as value dossiers, budget-impact briefs, account calculators, and executive presentations.
I would assess each market's perspective, comparator set, treatment pathway, costing sources, utility expectations, discounting conventions, and evidentiary standards. The model should be adaptable to local epidemiology, reimbursement rules, and data availability while retaining a consistent validated core structure. I would also engage local market-access experts early to ensure alignment with bodies such as NICE, CADTH, PBAC, IQWiG, and relevant Japanese processes.
I would use a structured prioritization framework that weighs strategic product milestones, payer evidence gaps, reimbursement risk, potential patient and commercial impact, feasibility, and time to evidence. I would align priorities with cross-functional stakeholders and distinguish essential evidence needed for near-term decisions from longer-term differentiating research. I would then establish clear owners, timelines, decision points, and publication plans to maximize the value of available resources.
Position Summary
We are seeking a strategic, analytical, and highly collaborative leader to serve as our
Associate Director/Senior Manager of Health Economics & Outcomes Research
(HEOR) Oncology. In this high-impact role, you will lead the development and execution
of health economic and outcomes evidence demonstrating the clinical and economic
value of Natera’s precision molecular diagnostic technologies across oncology and
emerging indications.
You will develop health economic models, generate real-world and clinical-trial
evidence, lead HEOR publication initiatives, and translate complex clinical and
economic data into compelling evidence supporting market access, reimbursement,
payer adoption, clinical adoption, and commercialization. Working across Medical
Affairs, Clinical Development, Biostatistics, Market Access, Commercial, Marketing,
Regulatory, and Business Development, you will help integrate HEOR evidence
throughout the product lifecycle—from clinical development and evidence generation
through publication, reimbursement, and payer adoption.
This is a strategic role for an experienced HEOR professional who combines strong
technical capabilities with scientific communication, business acumen, and the ability to
influence cross-functional evidence strategy.
Why Join Us
At Natera, you will have the opportunity to shape the economic evidence strategy
supporting innovative precision diagnostics and biomarker-guided approaches to patient
care. You will work at the intersection of clinical evidence, health economics, market
access, and commercialization, translating clinical innovation into measurable value for
patients, providers, health systems, and payers.
You will collaborate with internal leaders, investigators, key opinion leaders, and
external research partners to generate evidence capable of influencing reimbursement
decisions, clinical adoption, health technology assessments, and healthcare policy
across U.S. and global markets.
Key Responsibilities
Health Economic Modeling & Value Demonstration: Lead the development,
validation, and application of health economic models, including budget impact,
cost-effectiveness, cost-utility, cost-consequence, ROI, decision-tree,
Markov/state-transition, partitioned-survival, and other economic models.
Develop scenario and sensitivity analyses that quantify the clinical and economic
value of precision diagnostics across different payer and healthcare-system
perspectives.
Clinical Development & HEOR Evidence Strategy: Partner with Clinical
Development, Medical Affairs, Biostatistics, and other cross-functional teams to
integrate HEOR objectives into prospective clinical studies, including healthcare
resource utilization, economic endpoints, patient-reported outcomes, quality-of-
life measures, cost-data collection, and real-world evidence strategies. Ensure
evidence-generation plans anticipate future payer, reimbursement, and HTA
requirements.
Real-World Evidence & Outcomes Research: Analyze clinical-trial,
observational, and real-world datasets to evaluate healthcare resource utilization,
cost of care, treatment pathways, diagnostic utilization, clinical utility, comparative
effectiveness, patient outcomes, survival, budget impact, and quality-adjusted life
years. Translate findings into actionable evidence supporting clinical, payer, and
business decisions.
Publication & Scientific Evidence Leadership: Lead HEOR publication
strategy and development of peer-reviewed manuscripts, scientific abstracts,
conference posters, oral presentations, white papers, and technical reports.
Coordinate publication plans and timelines with investigators, key opinion
leaders, academic collaborators, and external research partners to ensure
evidence generation is aligned with strategic business priorities.
Market Access & Payer Evidence: Partner with Market Access, Medical Affairs,
Marketing, and Commercial teams to translate HEOR evidence into payer value
propositions, budget impact summaries, value dossiers, reimbursement
materials, health economic briefs, health-system value calculators, account-
specific economic tools, and other evidence-based value communications.
Global HEOR Strategy: Develop and adapt health economic evidence and
payer models for the U.S. and international markets, including Europe, Japan,
Canada, Australia, and other priority geographies. Support reimbursement
submissions and evidence strategies aligned with HTA and payer requirements
across healthcare systems.
Cross-Functional & External Collaboration: Serve as a strategic HEOR
partner across Medical Affairs, Clinical Development, Biostatistics, Market
Access, Commercial, Marketing, Regulatory, and Business Development.
Collaborate with external consultants, academic investigators, KOLs, and
research partners to execute high-quality evidence-generation initiatives.
Core Skills & Competencies
Health Economics & Outcomes Research: Deep understanding of health
economic modeling, outcomes research, healthcare resource utilization, real-
world evidence, cost-of-care analysis, comparative effectiveness, and value
assessment methodologies.
Economic Modeling: Demonstrated ability to develop and critically evaluate
budget impact, cost-effectiveness, cost-utility, ROI, decision-tree, Markov/state-
transition, and related economic models.
Payer & Market Access Strategy: Strong understanding of payer evidence
requirements and the ability to translate clinical and economic evidence into
compelling value propositions supporting reimbursement, coverage, and
adoption.
Evidence Generation & Clinical Strategy: Ability to integrate HEOR endpoints
and evidence requirements into clinical development and real-world research
programs, anticipating future reimbursement and HTA needs.
Scientific Communication & Publication: Strong scientific writing and
communication skills with experience translating complex analyses into
manuscripts, abstracts, presentations, value dossiers, payer materials, and
executive-level communications.
Cross-Functional Leadership: Proven ability to work across clinical, medical,
statistical, market access, commercial, and business functions and to influence
evidence strategy in a matrixed organization.
Global Perspective: Understanding of U.S. and international reimbursement
environments and major HTA frameworks, including ICER, NICE, CADTH,
PBAC, IQWiG, and Japanese reimbursement processes.
Qualifications
Advanced degree (PhD, PharmD, MD, DrPH, or Master's degree) in Health
Economics, Outcomes Research, Epidemiology, Public Health, Biostatistics,
Pharmacy, Health Services Research, or a related discipline.
5–10+ years of HEOR experience within biotechnology, pharmaceuticals,
diagnostics, medical devices, consulting, academia, or a related healthcare
environment.
Demonstrated experience developing and applying health economic models and
conducting outcomes research using clinical-trial and/or real-world datasets.
Experience supporting payer evidence generation, reimbursement strategy, value
dossiers, market access initiatives, and scientific publications.
Experience with precision medicine, molecular diagnostics, companion
diagnostics, ctDNA, molecular residual disease (MRD), donor-derived cell-free
DNA (dd-cfDNA), next-generation sequencing, biomarker-guided treatment
strategies, or oncology diagnostics is highly desirable.
Familiarity with advanced economic and analytical tools such as Microsoft Excel,
TreeAge Pro, R, SAS, STATA, Python, SQL, Tableau/Power BI, and statistical
analysis software is preferred.
The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.
Remote USA
$157,000—$218,000 USD
Compensation & Total Rewards
This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.
This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:
Annual performance incentive bonus
Long-term equity awards
Comprehensive health benefits (medical, dental, vision)
401(k) with company match
Generous paid time off and company holidays
Additional wellness and work-life benefits
Compensation Range
$191,800—$239,800 USD
OUR OPPORTUNITY
Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
WHAT WE OFFER
Competitive Benefits – Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!
For more information, visit www.natera.com.
Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.
If you are based in California, we encourage you to read this important information for California residents.
Link: https://www.natera.com/notice-of-data-collection-california-residents/
Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
For more information:
– BBB announcement on job scams
– FBI Cyber Crime resource page
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